非编码RNA作为结肠直肠多和癌症检测的潜在生物标志物
Samo Plut1,2,3, Aleksandar Gavric1,2,3, Damjan Glavač4,5
1Department of Gastroenterology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
International journal of molecular sciences
|May 14, 2025
概括
结肠直肠癌 (CRC) 是由于遗传和表观遗传变化而从聚中发展起来的. 像miRNA和lncRNA这样的非编码RNA显示为检测CRC和癌前多的早期生物标志物具有前途.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题,经常从癌前结肠直肠多,主要是腺瘤发展.
- CRC病变包括结肠上皮细胞中遗传和表观遗传变化的积累.
- 表观遗传异常越来越多地被认为是它们在CRC发育中的重要作用,也是早期分子标志.
研究的目的:
- 审查非编码RNA在结直肠癌表观遗传学中的作用.
- 突出特定非编码RNA的生物标志物潜力,用于早期CRC和聚检测.
主要方法:
- 关于结直肠癌表观遗传调节的当前文献的综述.
- 专注于微RNA (miRNA),长非编码RNA (lncRNA) 和其他非编码RNA.
- 对这些非编码RNA的生物标记物潜力的分析.
主要成果:
- 表观遗传变化,包括非编码RNA,在早期结直肠癌的发病过程中至关重要.
- miRNAs 和 lncRNAs 在结肠中起着关键的表观遗传调节者的作用.
- 这些非编码RNA显示出作为早期检测生物标志物的巨大潜力.
结论:
- 非编码RNA是结直肠癌发展中的重要表观遗传调节剂.
- 微RNA和lncRNAs的生物标志物潜力为早期检测结直肠癌和息肉提供了有前途的途径.
- 对非编码RNA生物标记物的进一步研究可以改善CRC患者的临床结果.
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