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烯胺对老鼠植入和决定化的影响

Hong-Yuan Yang¹, Hui-Na Luo², Zai-Mei Wang¹

¹Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountain Region, College of Animal Science, Guizhou University, Guiyang 550025, China.

International journal of molecular sciences

|May 14, 2025

概括

在小鼠中,烯胺 (ACR) 暴露显著减少了胚胎植入和 litter 尺寸. ACR破坏了关键的分子通路,导致通过氧化应激和铁死导致子宫决定性损伤和生殖毒性.

科学领域:

毒理学毒理学毒理学
生殖生物学生殖生物学
环境健康环境健康

背景情况:

烯胺 (ACR) 是一种已知的致癌物和在煮熟食品中发现的生殖毒素.
植入和决定化对于确定怀孕至关重要,但与ACR暴露有关的理解不佳.
这项研究调查了ACR对这些早期怀孕事件的影响.

研究的目的:

在小鼠模型中阐明烯胺影响子宫植入和决定化的机制.
在ACR暴露后识别子宫内膜和植入部位的分子变化.

主要方法:

雌性小鼠在饮用水中服用不同剂量的ACR (0,20,30毫克/公斤/天),持续3个月.
鼠标被交配以诱导怀孕,并在第4天和第5天评估植入和决定化.
分析了关键的子宫内膜受体,决定,氧化应激和铁亡标志物的表达.

主要成果:

与对照组相比,ACR暴露显著减少了胚胎植入数量和 litter 尺寸.
观察到子宫内膜受体性标记物的异常表达 (p-STAT3,MUC1,MSX1).
治疗ACR降低了决定化标记的调节,并改变了植入部位的氧化应激和铁亡相关蛋白质.

结论:

烯胺会损害小鼠的植入和决定.
通过干扰子宫内膜受体性和决定性,ACR破坏生殖过程.
氧化应激和铁亡路径与ACR诱导的生殖毒性有关.

关键词:

烯胺的使用方法个人化的决定性.铁性化 (ferroptosis) 是一种植入植入植入植入植入植入植入植入植入氧化应激是一种氧化应激.

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