从突触可塑性到神经退行:BDNF作为医学中的变革性目标
Corneliu Toader1,2, Matei Serban1,2,3, Octavian Munteanu4
1Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
International journal of molecular sciences
|May 14, 2025
概括
大脑衍生神经营养因子 (BDNF) 为神经系统疾病提供了治疗潜力. 创新的传递系统和生物标志物正在促进阿尔茨海默氏症和帕金森病等疾病的精准医学.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 精准医学是一门精准的医学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对突触可塑性,神经元生存和认知性至关重要.
- BDNF是治疗神经退行性和精神疾病的关键目标,包括阿尔茨海默病 (AD),帕金森病 (PD),严重抑郁症 (MDD) 和创伤后应激障碍 (PTSD).
- 临床应用的BDNF疗法面临的挑战在交付,患者的可变性,和复杂的信号通路.
研究的目的:
- 审查BDNF的当前发现,包括其调节途径,生物标志物和治疗策略.
- 突出BDNF相关疾病的创新传递系统和诊断/预后工具.
- 讨论将BDNF研究纳入系统健康,包括缺血组织和肠-大脑轴,并提出其临床实施的路线图.
主要方法:
- 对BDNF研究的文献综述,重点关注分子机制,治疗方法和临床应用.
- 分析创新的输送系统,如脂质纳米粒子mRNA疗法和CRISPR-dCas9表观遗传编辑.
- 检查诊断进步,包括多重面板和人性化的临床前模型 (iPSC衍生的神经元,器官).
主要成果:
- 新型的输送系统克服了血脑屏障和降解问题,提高了治疗疗效.
- 结合BDNF与tau和粉样β标记物的多重面板可以改善神经退行性疾病的早期检测和监测.
- 临床前模型和人工智能驱动的平台促进了定制和可扩展的BDNF治疗,显示了超越传统神经退行症的条件的希望.
结论:
- 对于一系列神经和精神疾病,BDNF具有显著的治疗前景,推动了精准医学的进步.
- 创新的输送方法,先进的生物标志物和临床前模型对于将BDNF研究转化为临床实践至关重要.
- 要将以BDNF为中心的疗法纳入全球医疗保健系统,需要制定一个全面的路线图,解决道德考虑和跨学科合作问题.
相关概念视频
Neuroplasticity
254
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
254
Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K
Long-term Potentiation
54.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.5K
Enzyme-linked Receptors
76.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
76.6K
Role of Neurotransmitters in Memory
340
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
340


