纳米喷雾干燥环氧德克斯/伊布洛芬复合物与气溶剂增强添加剂用于肺部药物输送
Anett Motzwickler-Németh1, Endre Körmendi1, Árpád Farkas2
1Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary.
International journal of molecular sciences
|May 14, 2025
概括
环氧增强了布洛在肺部的溶解性,改善了囊性纤维化症的治疗. 纳米喷雾干燥创造了有效的药物载体复合体,具有最佳的空气动力学特性,可增强药物释放.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 材料科学 材料科学 材料科学
背景情况:
- 水溶性较差的药物需要改进的输送系统.
- 肺部药物输送提供了较低的剂量和副作用,对诸如囊性纤维化等疾病有益.
- 环极素 (CDs) 是有效的载体,可以提高药物溶解度.
研究的目的:
- 使用纳米喷雾干燥来制备和表征循环德克斯/ (CD/IBU) 复合物.
- 评估这些复合物用于肺部输送的空气动力学特性和体外性能.
- 为了比较硫乙-β-环氧化 (SBECD) 和 (2-Hydroxy-3-N,N,N-trimethylamino) 乙-β-环氧化 (QABCD) 作为载体的疗效.
主要方法:
- 纳米喷雾干燥技术用于复杂的制备.
- 使用粒子大小分析,SEM,XRPD,DSC和FT-IR进行表征.
- 通过安德森级联冲击器,溶解和扩散试验进行体外评估,并通过in silico模拟进行补充.
主要成果:
- 优化的配方实现了大约50%的微粒分数,表明了良好的气溶潜力.
- 在所有配方中观察到快速的体外药物释放.
- 基于QABCD的配方显示,由于静电相互作用,与SBECD相比,膜扩散减少.
结论:
- 纳米喷雾干燥是一种可行的方法,用于准备CD/IBU复合体用于肺部输送.
- 配方表现出有利的空气动力学特性和快速释放药物.
- 选择循环二烯 (SBECD与QABCD) 影响药物扩散因相互作用,影响整体输送效率.
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