牙周病原体与急性冠状动脉综合征患者的炎症之间的关联
Ioana-Patricia Rodean1,2, Vasile-Bogdan Halațiu1,2, Teodora Maria Popa1,2
1George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
International journal of molecular sciences
|May 14, 2025
概括
与特定病原体相关的严重牙周病 (PD) 会增加炎症,并使急性冠状动脉综合征 (ACS) 患者的脂质样本恶化. 牙周治疗可能有助于预防ACS.
科学领域:
- 心脏病学 心脏病学
- 牙周病学 牙周病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 牙周病 (PD) 和急性冠状动脉综合征 (ACS) 之间的联系通常归因于系统性炎症和动脉样硬化.
- 在ACS患者中,PD严重程度,特定的牙周病原体和全身炎症之间的准确相关性需要进一步澄清.
研究的目的:
- 调查牙周病 (PD) 严重程度与全身炎症生物标志物之间的关联.
- 评估在被诊断为急性冠状动脉综合征 (ACS) 的患者中,PD严重程度和脂质样本之间的关系.
主要方法:
- 42名患有PD的ACS患者根据牙周病原体被分为两组:红色复合物 (RC) 和红色复合物 (ROC).
- 进行牙科检查和从牙周口袋取DNA样本以确定病原体.
- 系统性炎症标志物和脂质概况在两个组中都得到了评估.
主要成果:
- RC组表现出明显更高的炎症标志物水平,包括单细胞与淋巴细胞和血小板与淋巴细胞的比率,C反应蛋白和尿酸.
- 与ROC组相比,RC组的患者也显示出明显更高的低密度脂蛋白 (LDL) 胆固醇和较低的高密度脂蛋白 (HDL) 胆固醇水平.
- 炎症标志物在RC组中通常更明显.
结论:
- 病发症的严重程度,特别是红色和色复杂病原体的存在,与ACS患者的不良脂质概况和升高的全身炎症有关.
- 这些发现表明,牙周干预可以在预防ACS方面发挥作用.
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