揭开维生素D状态在原发性甲状腺功能障碍症中的悖论:偶然发现还是意想不到的后果?
Oriana-Eliana Pelineagră1,2,3, Ioana Golu1,2,3, Melania Balaș1,2,3
12nd Department of Internal Medicine-Discipline of Endocrinology, "Victor Babes" University of Medicine and Pharmacy, P-Ta Eftimie Murgu 2, 300041 Timisoara, Romania.
International journal of molecular sciences
|May 14, 2025
概括
低于最佳的维生素D状态在原发性甲状腺功能障碍症中很常见. 这项研究揭示了正常血患者的维生素D和之间的反相关性,这表明改变了平衡,而不是缺乏.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
背景情况:
- 低于最佳的维生素D状态经常在一次性甲状腺功能障碍症 (PHPT) 中观察到.
- 在PHPT管理决策中,维生素D的状态经常被忽视.
- PHPT的常态血性表型被低诊断,其维生素D状态需要进一步调查.
研究的目的:
- 调查PHPT患者的维生素D状况,重点关注常态血症表型.
- 在PHPT中探索维生素D,副甲状腺激素 (PTH) 和水平之间的关系.
- 评估副甲状腺切除术对维生素D水平的影响.
主要方法:
- 对53名PHPT患者 (高血和正常血组) 的回顾性研究.
- 对25氧维生素D (25OH维生素D),血清和完整的副甲状腺激素 (iPTH) 水平的分析.
- 进行了相关性和回归分析,以确定水平的预测因素和与腺瘤体积的关系.
主要成果:
- 正常血症PHPT患者的目标器官参与与高血症患者相似.
- 在正常血性PHPT中观察到25OH维生素D和血清之间的反相关性 (p = 0.048).
- iPTH和25OH维生素D是水平的显著预测因素 (p < 0.0001; R2 = 0.571).
- 腺瘤体积与25OH维生素D负相关 (p = 0.021),但在混分析后变得微不足道.
- 手术后的25OH维生素D水平在副甲状腺切除术后增加.
结论:
- 在PHPT中,PTH和维生素D之间存在复杂的相互作用,特别是在normcalcemic表型中.
- 维生素D和之间的反相关性表明,在PHPT中,的平衡有所改变.
- 维生素D的状态需要在PHPT的管理中仔细考虑,包括正常血变体.
相关概念视频
The Parathyroid Glands
1.8K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.8K
Hormones and Bone Tissue
2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
Skeleton and Calcium Homeostasis
4.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.3K
Role of Skin in Vitamin D Synthesis
4.9K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
4.9K
Roles of Electrolytes: Calcium and Phosphate
128
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
128
Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K


