孕产妇营养编程:围产期高脂肪饮食暴露后的性别特异性心血管和免疫结果
Yasir Alsiraj1,2, Hong Huang1, Robin Shoemaker1
1Department of Pediatrics, College of Medicine, University of Kentucky, 138 Leader Ave, Lexington, KY 40536-0200, USA.
Nutrients
|May 14, 2025
概括
怀孕期间母亲的高脂肪饮食对男性和女性不同影响后代的心血管健康. 女性表现出基线问题,而男性表现出与压力相关的脆弱性,突出性别特异性的影响.
科学领域:
- 心血管生理学心血管生理学
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 围产期高脂肪饮食 (pHFD) 对后代的长期心血管影响尚不清楚.
- 怀孕期间母亲的饮食可能会影响后代的成年健康.
- 假设性别特异的心血管和免疫反应.
研究的目的:
- 调查长期高脂肪饮食暴露对子女的性别特异性心血管和免疫影响.
- 为了确定母亲的高脂肪饮食是否会改变成人心血管功能和男性和女性后代的炎症反应.
主要方法:
- 研究了C57BL/6小鼠的后代,这些小鼠被养为围产期高脂肪 (pHFD) 或控制 (pCD) 饮食.
- 心血管功能在8周后通过基线和异二醇压力测试进行评估.
- 对脂多糖 (LPS) 的急性炎症反应在9周后被测量.
主要成果:
- 男性pHFD后代的心血管功能基线正常,但对异二醇的反应减弱.
- 女性pHFD后代表现出降低了基线心血管参数,没有应激反应变化.
- 炎症标志物 (TNF-α,IL-6) 在LPS后的对照女性中最高.
结论:
- 围产期高脂肪饮食诱导后代发生性别特异的心血管和免疫适应.
- 女性表现出基线心血管功能障碍;男性在压力下表现出潜在的脆弱性.
- 这些发现强调了母亲饮食对后代心脏代谢风险的作用,并建议针对性别的营养干预措施.
相关概念视频
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...


