妊娠糖尿病后人乳代谢物的变化:与婴儿成长的关联
Alice Fradet1,2,3,4,5, Line Berthiaume2, Laurie-Anne Laroche4
1Centre NUTRISS-Nutrition, Health, and Society, Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec City, QC G1V 0A6, Canada.
Nutrients
|May 14, 2025
概括
孕期糖尿病 (GDM) 会改变母乳成分,影响婴儿的生长. 特定的牛奶代谢物在有或没有GDM的母亲之间存在差异,影响婴儿的发育和代谢.
科学领域:
- 代谢学 代谢学 代谢学
- 人类牛奶中的寡糖化物
- 婴儿营养 婴儿营养
背景情况:
- 孕期糖尿病 (GDM) 与儿童肥胖和糖尿病风险增加有关.
- 人母乳的成分可能会被GDM改变,可能会影响婴儿的生长,但这并未得到充分理解.
研究的目的:
- 调查GDM与母乳成分之间的关联.
- 检查乳中的GDM相关变化如何影响婴儿生长,重点关注能量代谢分子.
主要方法:
- 在产后2个月的20名GDM+和29名GDM-母亲的横截面研究.
- 对24种母乳代谢物进行GC-MS分析.
- 收集母亲的人类测量和血糖数据,以及婴儿生长记录.
主要成果:
- 来自GDM+母亲的母乳显示出更高水平的酸,糖,乌拉,酸和胆固醇.
- 母亲血糖与特定代谢物 (糖酸盐,酸盐,氨酸,谷氨酸) 的相关性根据GDM状态不同.
- 在GDM+母亲中,α-甲酸盐和甘氨酸水平与婴儿生长有负相关性.
结论:
- 产后乳腺瘤会影响产后母亲的健康,影响乳腺功能和牛奶成分.
- 人母乳中的GDM诱导的变化可能会影响婴儿的生长和新陈代谢.
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