时间限制禁食-尼古丁胺胺单核酸组合对通过线粒体激活和肠道微生物群调节的运动能力的影响
Jian Shi1,2, Tingting Zhuang3, Weiye Li1,2
1College of Food Science, South China Agricultural University, Guangzhou 510642, China.
Nutrients
|May 14, 2025
概括
时间限制禁食 (TF) 与尼古丁胺单核酸 (NMN) 补充剂相结合,显著提高了小鼠的运动表现. 这种组合可以增强线粒体功能,改善能量代谢,并积极调节肠道微生物群,以提高炼能力.
科学领域:
- 运动生理学和体育科学
- 营养生物化学 营养生物化学
- 线粒体生物学 线粒体生物学
背景情况:
- 对于运动员和健身爱好者来说,运动表现至关重要.
- 饮食干预措施,如时间限制禁食 (TF) 和NAD +补充剂,如尼古丁胺胺单核酸 (NMN),显示了提高运动能力的潜力.
- TF和NMN对运动表现的综合作用在很大程度上仍未被探索.
研究的目的:
- 研究时间限制禁食 (TF) 和尼古丁胺 mononucleotide (NMN) 补充剂对运动表现的协同效应.
- 阐明潜在的机制,包括线粒体功能,代谢变化和肠道微生物群调节.
- 在临床前模型中评估对运动能力,耐力和恢复的影响.
主要方法:
- 利用昆明小鼠和C2C12细胞来评估TF和NMN的联合作用.
- 通过运动行为测试,血液气体分析和氧化应激标志物评估运动能力.
- 分析了肌肉发育,线粒体功能 (基因表达,蛋白质分析,酶活性),以及肠道微生物群组成和短链脂肪酸含量.
主要成果:
- TF和NMN联合治疗改善了线粒体动力学,生物合成,呼吸功能和氧化代谢.
- 观察到小鼠的耐力,四肢力量,运动协调和平衡显著改善,运动后氧化损伤减少.
- 干预增加了肠道微生物群的多样性,并提高了有益细菌 (例如,鲁米诺科克,罗斯布里亚,阿克尔曼西亚) 和短链脂肪酸的调节.
结论:
- TF和NMN的组合有效地增强了线粒体功能和能量代谢.
- 调节肠道微生物群和短链脂肪酸有助于改善运动表现.
- 这种协同方法为提高运动能力提供了一个有希望的策略,并为动理学中的应用提供了理论基础.
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