营养不良和儿童肠道感染:叙述性审查
Maria Clara da Cruz Carvalho1, Samilly Albuquerque Ribeiro2, Lélia Sales de Sousa3
1Graduate Program in Health Science, Center for Health Science, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
儿童营养不良与肠道感染和肠道屏障功能受损有关,影响生长和发育. 解决这个循环对于长期儿童健康结果至关重要.
科学领域:
- 儿童营养和胃肠道学
- 传染病与公共卫生问题
- 发育儿科 发育儿科
背景情况:
- 营养不良影响全球数以百万计的儿童,并对长期健康造成重大后果.
- 肠道感染和胃肠道屏障功能受损是儿童营养不良的主要原因.
- 感染和营养不良的循环会导致认知缺陷,生长不良和成人代谢疾病.
研究的目的:
- 审查导致儿童营养不良的因素,强调肠道感染和肠道透性.
- 探索肠道病原体,肠道屏障功能障碍和儿童发育之间的关系.
- 综合目前关于5岁以下儿童感染-营养不良循环的证据.
主要方法:
- 在2024年7月至2025年3月期间发表的研究的叙述性综述.
- 在Medline/PubMed,Web of Science和Scopus数据库中进行的搜索.
- 包括5岁以下儿童的研究,重点关注营养不良,肠道感染或透性标志物;排除非治疗研究,书籍,病例报告和论文.
主要成果:
- 在肠道病原体,腹/非腹和营养不良之间发现了强烈的关联.
- 在营养不良儿童中发现的常见病原体包括Shigella,肠毒性大肠杆菌,EAEC和Cryptosporidium.
- 胃肠道屏障功能的恶化会影响营养吸收,对儿童的生长和发育产生负面影响.
结论:
- 审查证实了感染-营养不良循环和不良儿童发育结果之间的重要联系.
- 未来的研究应该专注于个性化的营养疗法,长期的肠道健康,以及肠道微生物组的作用.
- 了解和干预这个循环对于改善儿童健康和预防长期后果至关重要.
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