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小肠细菌过度生长和儿科肥胖症-一项系统性审查
Ana Maria Koller1, Maria Oana Săsăran2, Cristina Oana Mărginean3
1Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street No 38, 540136 Targu Mures, Romania.
Nutrients
|May 14, 2025
概括
小肠细菌过度生长 (SIBO) 在肥胖儿童中很常见,导致炎症和代谢问题. 早期诊断和针对性治疗,如益生菌可以改善儿童肥胖的结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
背景情况:
- 儿童肥胖是一个重要的全球健康问题.
- 肥胖与非酒精性脂肪性肝病 (NAFLD) 等代谢障碍有关.
- 小肠细菌过度生长 (SIBO) 可能会使肥胖儿童的代谢功能障碍和炎症恶化.
研究的目的:
- 审查肥胖儿童中SIBO的流行情况.
- 检查SIBO和炎症/代谢标志物之间的关联.
- 在这个人群中评估SIBO的诊断和治疗策略.
主要方法:
- 在PubMed,Scopus和Web of Science (2010年至今) 的系统文献搜索.
- 关键词包括SIBO,患病率,炎症标志物,代谢状态,肠道微生物组,失生症和肥胖儿童.
- 审查的重点是患病率,关联和治疗疗效.
主要成果:
- 在肥胖儿童中经常检测到SIBO,通常与肠道失调症一起.
- SIBO与营养吸收受损,短链脂肪酸减少,肠道透性增加,内毒性病和慢性炎症有关.
- 诊断方法显示出不一致性,但诸如益生菌,益生菌,饮食和抗生素等治疗方法显示出有前途.
结论:
- 早期识别和定制治疗SIBO对于管理儿童肥胖的代谢并发症至关重要.
- 解决SIBO可能会改善肥胖儿童的整体健康结果.
- 进一步验证诊断和治疗方法是有必要的.
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