临床试验:地中海低FODMAP饮食缓解非便秘的症状 IBS随机对照研究和volatomics分析
Arezina N Kasti1, Konstantinos Katsas1, Dimitrios E Pavlidis2
1Department of Nutrition and Dietetics, Attikon University General Hospital, 12462 Athens, Greece.
Nutrients
|May 14, 2025
概括
与标准指南相比,地中海低FODMAP饮食 (MED-LFD) 显著改善了易怒肠综合征 (IBS) 症状和生活质量. 这种饮食方法也导致患者的便挥发性化合物减少.
科学领域:
- 胃肠病学 胃肠病学
- 饮食科学 饮食科学
- 微生物组研究 微生物组研究
背景情况:
- 刺激性肠综合征 (IBS) 影响大约20%的患者,许多人将症状与食物摄入联系起来.
- 低FODMAP饮食是一种公认的有效干预措施,用于控制IBS症状.
研究的目的:
- 为了比较地中海低FODMAP饮食 (MED-LFD) 与NICE IBS症状管理指南的有效性.
- 在MED-LFD干预后评估便挥发性化合物水平的变化.
主要方法:
- 108名罗马IV型IBS患者 (非便秘) 被随机分配到MED-LFD或NICE指南中.
- 主要终点包括症状严重程度的变化和干预和6个月后的响应率.
- 使用气体染色学/质谱学分析了便中的挥发性化合物.
主要成果:
- 与NICE组相比,MED-LFD组在症状严重程度,响应率和坚持方面表现出显著更大的改善.
- 所有次要终点,包括生活质量和症状负担,也显示MED-LFD显著改善.
- 作为治疗反应的最强预测因素,MED-LFD干预是最强的预测因素,没有报告严重不良事件. 便短和分支链脂肪酸显著减少.
结论:
- 在管理非便秘性IBS症状和改善生活质量方面,MED-LFD优于NICE的建议.
- 需要进一步的研究来确认降低挥发性化合物水平是否可以作为IBS饮食干预反应的客观标记.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
277
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
277
01:21Drugs for Treatment of Constipation-Predominant IBS
119
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
119
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
128
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
128
01:17Drugs for Treatment of Diarrhea-Predominant IBS
126
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
126
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
101
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
101
01:17Irritable Bowel Syndrome I: Introduction
210
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
210