用植物来源的精油准肠-大脑轴:植物性大麻素和超越
Luca Camarda1, Laura Beatrice Mattioli1,2, Ivan Corazza2,3
1Department of Pharmacy and Biotechnology (FaBiT), Food Chemistry and Nutraceutical Lab, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Nutrients
|May 14, 2025
概括
精油 (EO) 通过影响神经递质和肠道细菌来调节肠-大脑轴 (GBA) 的潜力. 虽然大麻精油 (CEO) 有好处,但长期使用需要谨慎,因为它会影响微生物群.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠-大脑轴 (GBA) 是胃肠道和中枢神经系统之间的关键双向通信通道.
- 精油 (EOs) 是天然化合物,具有调节GBA的新兴潜力.
研究的目的:
- 综合分析最近关于EO对GBA影响的文献.
- 调查内分泌系统,大麻衍生的EO和其他植物性EO在GBA调节中的作用.
主要方法:
- 文献综述侧重于EO和GBA的研究.
- 对内分泌系统,肠道微生物群,神经炎症和神经传递的影响的分析.
- 对大麻精油 (CEO) 和其他植物EO (迷香,衣草,白树,红) 的检查.
主要成果:
- 大麻精油 (CEO) 与大麻素受体 (CBR1,CBR2) 相互作用,调节肠道运动,免疫反应和神经传递.
- 急性CEO的使用可降低肠道炎症和透性,但长期使用可能会改变肠道微生物群并影响认知.
- 其他EO (迷香,衣草,白,) 显示出神经递质调节,肠道微生物群平衡和减少神经炎症的潜力.
结论:
- 通过神经递质调节,微生物群平衡和抗炎作用来调节GBA,EO显示出希望.
- 植物大麻素具有治疗价值,但长期使用需要谨慎对待微生物群的影响.
- 未来的研究应该专注于以EO为基础的干预措施,以恢复GBA平衡,并解决神经退行性和胃肠道疾病.
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