基于证据的饮食治疗在炎症性肠病中的实际应用:可读性计划
Gina L Trakman1,2,3, Erin E Russell1,2, Amy L Hamilton1,2
1Department of Gastroenterology, St Vincent's Hospital, Melbourne 3065, Australia.
Nutrients
|May 14, 2025
概括
诸如克罗恩氏病排除饮食 (CDED) 和全食饮食之类的治疗饮食被炎症性肠病 (IBD) 患者所接受,有望改善疾病活动和生活质量.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 饮食疗法是一种饮食疗法.
背景情况:
- 炎症性肠病 (IBD) 管理包括饮食干预措施,对其耐受性和有效性的实际数据有限.
- 众所周知,排他性肠道营养 (EEN) 和CDED可以在克罗恩病中诱导缓解.
- 低硫,植物性饮食和全食,低添加剂的方法正在出现IBD.
研究的目的:
- 评估患者对饮食疗法的满意度,坚持和有效性,在IBD护理的DELECTABLE计划中进行评估.
- 评估特定饮食对生活质量和疾病活动标志物的影响.
- 收集有关IBD患者治疗饮食的现实应用的证据.
主要方法:
- 一项前性,开放的,由营养学家主导的研究,涉及克罗恩病 (CDED或WFD) 和性结肠炎 (UCD或WFD) 患者.
- 主要结局:12周饮食满意度和坚持;次要结局:生活质量 (QoL),疾病活性 (CDAI,部分梅奥),以及生化标志物 (CRP,便calprotectin).
- 重复测量ANOVA/弗里德曼测试和配对t测试/威尔科克森签名-等级测试被用于饮食手臂内的时间点分析.
主要成果:
- 在76名注册患者中,有64人完成了为期12周的计划.
- 初始饮食满意度高,在CDED上稳定,在WFD上改善 (p=0.03).
- 在所有饮食中高度坚持;在WFD上显著减少食品添加剂摄入量 (p=0.009).
- 在CDED和WFD上观察到改善的QOL (p<0.001) 和减少的疾病活动标志物 (CRP,calprotectin,CDAI,部分Mayo).
结论:
- 均衡的治疗饮食是可行的,并且在IBD患者护理中得到了很好的接受.
- 这些饮食干预措施对疾病活动和生活质量产生了有前途的影响.
- 这项研究支持将饮食疗法纳入IBD常规管理中.
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