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短肠综合症患者的微量营养状况 断绝了亲肠支的患者
Nastasia Mattio1, Charlotte Juin1, Madeleine Lauverjat1
1Hépato-Gastroentérologie et Assistance Nutritionnelle, Hôpital Lyon Sud, 165 Chemin du Grand Revoyet, 69495 Pierre Bénite CEDEX, France.
几乎所有患有短肠综合征 (SBS) 的成年人经历了亲肠支 (PS) 断奶后的微量营养素耗尽. 长期监测营养状况对于这些患者来说至关重要,以有效地管理缺陷.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床医学 临床医学
背景情况:
- 短肠综合征 (SBS) 影响营养吸收,往往需要肠道支 (PS).
- 虽然许多SBS患者已经断奶PS,但断奶后微量营养素缺乏的患病率仍未得到充分研究.
- 这项研究解决了SBS患者在PS停止后了解微量营养素状况的差距.
研究的目的:
- 为了确定微量营养素耗尽在SBS的成年人中断奶后从肠道支 (PS) 断奶后的流行率.
- 为了确定与这些微量营养素枯竭相关的潜在风险因素.
- 为临床实践提供有关SBS患者长期营养监测的信息.
主要方法:
- 在2011年至2021年期间,从PS断奶的161名SBS患者的回顾性分析.
- 断奶后一年多的42名患者的血微量营养素状况评估.
- 统计分析以确定枯竭和临床因素之间的关联.
主要成果:
- 观察到微量营养素枯竭的高患病率,42名患者中有40名 (95%) 显示至少有一种缺乏.
- 维生素D,E,,铜和是最常见的缺少微量营养素 (>50%的患者).
- 长期使用质子抑制剂 (PPI),更长时间使用PS,以及在断奶时更高的能量输注率与消耗的增加有关.
结论:
- 在PS戒断后,SBS患者中微量营养素耗尽几乎是普遍的.
- 建议对SBS患者进行微量营养素状况的持续监测,即使在PS.成功断奶后也是如此.
- 需要进一步的大规模研究来验证这些发现并指导管理策略.
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