纳米-酸/聚甲基酸) 复合骨架:表面活性剂的表面效应
Muhammed Enes Oruc1, Nilüfer Evcimen Duygulu2, Betul Onder2
1Department of Chemical Engineering, University of Doha for Science and Technology, Doha 24449, Qatar.
Polymers
|May 14, 2025
概括
用纳米-酸 (n-HA) 强化和用三聚酸 (STTP) 稳定的聚甲基酸 (PMMA) 纳米纤维支架,由于改善结构和机械特性而没有细胞毒性,对骨组织工程有很大的希望.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 纳米技术纳米技术
背景情况:
- 骨组织工程需要先进的脚手架,具有合适的机械性能和生物相容性.
- 聚甲酸 (PMMA) 是一种多用途的聚合物,但其在骨再生中的应用可能受到其机械强度和生物活性的限制.
- 纳米酸 (n-HA) 是促进骨再生的关键成分,因为它与天然的骨矿物质相似.
研究的目的:
- 为了制造和表征聚甲基酸 (PMMA) 纳米纤维支架,用纳米-酸 (n-HA) 加固.
- 研究三聚酸盐 (STTP) 作为表面活性剂对PMMA纳米纤维内n-HA的分散和形态的影响.
- 评估开发的n-HA增强的PMMA纳米纤维支架的机械性能和生物相容性,用于骨组织工程应用.
主要方法:
- 使用STTP作为表面活性剂的电制造PMMA/n-HA纳米纤维支架.
- 使用扫描电子显微镜 (SEM),能量分散光谱 (EDS) 和传输电子显微镜 (TEM) 进行纤维形态和组成的表征.
- 通过拉力测试评估机械性能,并使用L929纤维细胞细胞毒性评估.
主要成果:
- 添加STTP有效地稳定了n-HA分散,导致均的PMMA_10_HA_S纳米纤维,平均直径为345.40±53.55nm.
- 用n-HA增强的PMMA纳米纤维表现出增强的机械性能,最大拉伸应力为4.16 ± 2.13 MPa,延长率为7.1 ± 1.95%.
- 细胞毒性测定证实,PMMA_10_HA_S纳米纤维在高达100毫克/毫升的度下对L929纤维细胞细胞没有不良影响.
结论:
- 纳入n-HA和稳定STTP显著改善了PMMA纳米纤维的结构完整性和机械性能.
- 开发的PMMA_10_HA_S纳米纤维支架显示出出色的生物相容性.
- 这些发现表明,STTP稳定的n-HA增强的PMMA纳米纤维支架是未来骨组织工程应用的有希望的候选者.
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