聚合物微粒作为生物活性的纳米载体
Petar D Petrov1, Slavena Davidova2,3, Galina Satchanska2,3
1Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St., Bl. 103A, 1113 Sofia, Bulgaria.
Polymers
|May 14, 2025
概括
聚合物微粒 (PMs) 通过提高其稳定性和传递性来增强生物活性 (BPs) 的治疗潜力. 本综述探讨了使用PMs为各种疾病提供BP的进展.
科学领域:
- 生物化学和药理学 生物化学和药理学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 生物活性 (BPs) 具有广泛的抗微生物和治疗特性,但由于稳定性,生物可用性和潜在的细胞毒性差,在临床应用中面临挑战.
- 在聚合物微粒 (PMs) 中封装提供了一种有希望的策略来克服这些局限性,提高BP的药理特征和安全性.
研究的目的:
- 审查最近在使用生物活性酸的菌根载体方面取得的进展.
- 讨论BP的作用方式和PM的特征.
- 批判性地评估携带BP的菌根系统的优点,缺点,挑战和未来前景.
主要方法:
- 关于包装生物活性 (BPs) 的聚合物微粒 (PMs) 的最近研究的文献综述.
- 对封装BP的药理活性 (抗微生物,抗癌,抗炎,免疫调节,抗糖尿病) 的分析.
- 评估PM作为药物输送载体的特性和机制.
主要成果:
- PMs有效地提高了BP的稳定性,生物可用性和安全性.
- 细胞输送系统已经显示出具有多种治疗活动的BP显著潜力.
- 最近的进展凸显了PMs在提高BP有效性的多功能性.
结论:
- 聚合物微粒是改善生物活性的治疗应用的强大策略.
- 对细胞系统的进一步研究对于克服当前挑战和实现BP在医学中的全部潜力至关重要.
- 细胞输送BP对开发各种疾病领域的新疗法具有重大前景.
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