Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

257
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
257
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

2.7K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
2.7K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

156
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
156
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

104
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
104
Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

12.2K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
12.2K
Polymers: Molecular Weight Distribution01:10

Polymers: Molecular Weight Distribution

3.1K
For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Coupled Orientational Disorder and Hydrogen-Bond Destabilization Drive Anisotropic Surface Melting in Curcumin Polymorphs.

The journal of physical chemistry letters·2026
Same author

Thermal Behavior and Local Structural Organization in Curcumin Polymorphs' Bulk Phase: A Molecular Dynamics Simulation Analysis.

The journal of physical chemistry. B·2025
Same author

Impact of Intermolecular Forces on Structural Changes and Local Density Fluctuations of CO<sub>2</sub> in Liquid and Supercritical Phases.

The journal of physical chemistry letters·2025
Same author

Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices.

Pharmaceutics·2024
Same author

Widom Line in Supercritical Water in Terms of Changes in Local Structure: Theoretical Perspective.

The journal of physical chemistry letters·2024
Same author

Pressure Dependence of the Crystallization Rate for the S-Enantiomer and a Racemic Mixture of Ibuprofen.

Crystal growth & design·2021

相关实验视频

Updated: May 15, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

1.9K

探索稳定性和动力学之间的关系,以聚合物为基础的无形固体分散剂的制药应用.

Emeline Dudognon1, Jeanne-Annick Bama1, Frédéric Affouard1

  • 1Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207-UMET-Unité Matériaux et Transformations, F-59000 Lille, France.

Polymers
|May 14, 2025
PubMed
概括

特尔费纳丁和聚乙烯烯 (PVP) 的无形固体分散 (ASD) 显示了药物稳定性的提高. 分子动力学揭示了结构异质性,表明了不同的无形相,影响药物再结晶.

关键词:
聚乙烯皮罗利胺的多乙烯.特尔芬阿丁 (terfenadine) 是一种药物.无形固体分散的分散.玻璃过渡过程中的玻璃过渡.分子动力学分子动力学溶解度 溶解度 溶解度 溶解度

更多相关视频

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.0K
Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.3K

相关实验视频

Last Updated: May 15, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

1.9K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.0K
Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.3K

科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 物理化学 物理化学

背景情况:

  • 无形固体分散 (ASDs) 通过防止药物再结晶来增强药物的生物可用性.
  • 在ASD中确切的稳定机制,特别是分子动态的作用,需要进一步阐明.

研究的目的:

  • 为了研究无形固体分散 (ASDs) 中不稳定的分子动力学.
  • 了解PVP K12在ASD中稳定terfenadine的作用.

主要方法:

  • 使用了温度调节差异扫描热量计 (MDSC) 和介电松光谱.
  • 分析了由聚乙烯烯利 (PVP K12) 和特尔费纳丁组成的ASD,在各种组成中.

主要成果:

  • 自闭症患者被特纳丁超和,PVP K12有效减缓分子动力学和抑制药物再结晶.
  • 虽然MDSC显示同质性 (单玻璃过渡),但介电光谱检测显示动态异质性低于30%PVP.
  • 这种动态异质性表明存在两个不同的无形相,其组成和动态不同.

结论:

  • 特尔费纳丁/PVP ASD 的动态异质性表明结构异质性,具有共存的无形阶段.
  • 该研究提供了关于ASD分子动力学,相位行为和稳定机制之间的复杂相互作用的见解.