使用局部分歧指数的多发性硬化症分类:国家空间重建的参数选择
L Eduardo Cofré Lizama1,2, Liuhua Peng3, Tomas Kalincik4,5
1Department of Allied Health, School of Health Sciences, Swinburne University of Technology, Hawthorn, Melbourne, VIC 3122, Australia.
Sensors (Basel, Switzerland)
|May 14, 2025
概括
当地分歧指数 (LDE) 的计算可以有效地将多发性硬化症 (pwMS) 患者与对照者区分开来. 使用固定的参数来计算LDE简化了其作为移动性生物标志物的使用.
科学领域:
- 生物医学工程 生物医学工程
- 神经学 神经学
- 康复科学 康复科学 康复科学
背景情况:
- 在患有多发性硬化症 (pwMS) 的人中,步行稳定性受损.
- 以前使用局部分歧指数 (LDE) 评估 pwMS 步行稳定性的研究表明,由于计算方法不同,结果各不相同.
- 标准化LDE计算对于可靠的比较和临床应用至关重要.
研究的目的:
- 调查不同的状态空间重建参数对LDE计算如何影响pwMS的分类准确性.
- 确定LDE计算的最佳参数,以作为多发性硬化症中可靠的移动性生物标志物.
主要方法:
- 55名pwMS和23名对照人进行了5分钟的行走测试.
- 使用三组参数 (试验特定,中位数,固定d=5/τ=10) 和来自胸和腰部传感器的各种传感器数据 (垂直,中侧,前后加速,正常,3D) 来计算LDE.
- 使用二次差异分析 (QDA) 来比较不同LDE计算方法的分类准确性.
主要成果:
- 最高的分类准确度 (84%) 是通过使用LDE从固定参数 (d=5, τ=10) 的胸上装的正常加速度数据中获得的,其中将步行速度作为共同变量.
- 使用腰部传感器进行的LDE计算,与胸骨传感器相比,分类准确性较低.
结论:
- 固定参数 (d=5, τ=10) 用胸骨规范加速度数据进行LDE计算,提供了pwMS的最佳分类.
- 标准化LDE计算参数简化了其作为多发性硬化症移动性生物标志物的实施.
- 这项研究提供了支持在MS研究和临床实践中对LDE计算方法达成共识的证据.
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