菌分泌动力学及其在重症患者中的作用:一个范围的综述
Yorschua Jalil1,2,3, L Felipe Damiani1,2,3, Patricio García-Valdés1,2
1Escuela de Ciencias de la Salud, Departamento de Kinesiología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 1270709, Chile.
Journal of clinical medicine
|May 14, 2025
概括
身体康复会影响重症患者的肌肉蛋白分泌,可能会防止器官功能障碍和肌肉衰竭. 需要进一步的研究来澄清这些系统性影响.
科学领域:
- 关键护理医学 关键护理医学
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 肌卡因,肌肉衍生的细胞因子,调节器官功能和新陈代谢.
- 它们除了防止肌肉消耗之外,还可以提供对重症监护室 (ICU) 并发症的保护.
研究的目的:
- 为了探索和总结关于严重病情的成年人中肌素分泌的证据.
- 在这个人群中研究肌肉激素的局部和全身效应.
主要方法:
- 根据乔安娜·布里格斯研究所的建议进行范围审查.
- 在多个数据库 (MEDLINE,Embase,CENTRAL,CINAHL,WoS,Scopus) 进行系统搜索,截至2023年2月.
- 包括在身体康复中接受重症成人肌肉蛋白分泌的初级研究.
主要成果:
- 包括17项研究 (2012-2023年),主要是RCT.
- 常被研究的肌动素是:互乐金-6,互乐金-10,瘤缩因子-α,互乐金-8和肌态素.
- 13项研究报告了肌分泌/基因表达的变化,但没有明确的模式出现.
结论:
- 危急病患者的myokine动态揭示了身体康复的系统影响.
- 这个领域显示出越来越多的兴趣和研究潜力.
- 挑战包括研究设计,样本大小和协议变异性,阻碍全面理解.
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