怀孕期间母亲暴露于细颗粒物质与前段失生症风险的关联:一项匹配的病例对照研究
Sooyeon Choe1,2, Kyung-Shin Lee3, Ahnul Ha4,5
1Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Journal of clinical medicine
|May 14, 2025
概括
在怀孕前和怀孕期间,母亲暴露于细颗粒物 (PM2.5) 与儿童前段失生症 (ASD) 的风险更高有关. 改善空气质量可能有助于预防这些先天性眼睛疾病.
科学领域:
- 环境健康 环境健康
- 眼科医生 眼科 眼科
- 生殖流行病学 生殖流行病学
背景情况:
- 暴露于颗粒物 (PM2.5) 是一个全球性的健康问题.
- 先天性眼睛异常,如前段失生症 (ASD),可以导致视力受损.
- 产前空气污染对ASD风险的影响需要进一步调查.
研究的目的:
- 调查孕前和怀孕期间母亲暴露于PM2.5与后代患ASD风险之间的关联.
- 量化与不同妊娠期中不同水平的PM2.5暴露相关的ASD风险.
主要方法:
- 一项涉及被诊断患有自闭症的儿童及其母亲的病例控制研究.
- 住宅中PM2.5暴露的估计是使用普遍的Kriging预测模型.
- 统计分析包括相对风险 (RR) 和95%置信区间 (CI),以潜在的混因素进行调整.
主要成果:
- 在怀孕前,第一和第二个三个月中增加PM2.5暴露与更高的ASD风险显著相关.
- 在这些时期,PM2.5的四分位数间范围 (IQR) 增加显示了1.14至1.18.8之间的相对风险.
- 从怀孕前到第三季度的总体PM2.5暴露也显著增加了ASD风险 (RR,1.13).
结论:
- 在怀孕前和怀孕期间,母亲对PM2.5的暴露是ASD的潜在风险因素.
- 这些发现强调了改善空气质量的重要性,以预防先天性眼睛异常.
- 需要进一步的研究来阐明空气污染和ASD发展之间的联系机制.
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