严重COPD恶化患者的死亡率预测因素
Elena Cojocaru1, Raluca Ecaterina Haliga2, Gianina-Valentina Băcescu Ene3
1Morpho-Functional Sciences II Department, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Journal of clinical medicine
|May 14, 2025
概括
较高的全身免疫炎症指数 (SII) 和中性粒细胞与淋巴细胞比率 (NLR) 预测了重症监护室 (ICU) 患有慢性阻塞性肺病 (AECOPD) 严重急性恶化患者的死亡率. 这些生物标志物可以帮助早期干预.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 慢性阻塞性肺病 (AECOPD) 的严重急性恶化是ICU入院和死亡的重要原因.
- 血液炎症生物标志物,如中性粒细胞与淋巴细胞的比率 (NLR) 和全身免疫炎症指数 (SII) 被用于疾病严重程度的评估.
研究的目的:
- 评估血液炎症生物标志物对AECOPD的ICU患者死亡率的预测价值.
- 在AECOPD中确定风险分层和早期干预的关键生物标志物.
主要方法:
- 对104名患有AECOPD的ICU患者进行了回顾性分析.
- 在幸存者和非幸存者的血液学指数 (NLR,PLR,MLR,dNLR,SII) 的比较.
- 包括后勤回归,卡普兰-梅尔和ROC曲线在内的统计分析.
主要成果:
- 更高的SII (OR: 1.92) 和NLR (OR: 2.89) 独立预测了AECOPD患者的死亡率.
- NLR>8.0和SII>1800与明显较低的存活率有关.
- SII (AUC=0.79) 和NLR (AUC=0.82) 显示出对死亡率的强大预测能力.
结论:
- NLR,MLR,PLR,dNLR和SII是ICU入院AECOPD患者死亡率的独立预测指标.
- 这些易于评估的生物标志物应纳入ICU风险模型,以便及时进行干预.
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