风险因素和癌症和心血管疾病的预防:一只和蛋的情况
Maurizio Giuseppe Abrignani1, Fabiana Lucà2, Vincenzo Abrignani3
1O.U. of Cardiology, P. Borsellino Hospital Marsala, ASP Trapani, 91025 Marsala, Italy.
Journal of clinical medicine
|May 14, 2025
概括
心血管疾病和癌症具有共同的风险因素和机制. 生活方式的改变和某些心脏药物在预防这两种疾病方面都很有前途,突出了它们的相互联系.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 心血管疾病 (CVD) 和癌症是全球主要的死亡原因.
- 这些疾病具有共同的病理生理机制和危险因素,包括慢性炎症,胰岛素抵抗,肥胖和代谢失调.
- 肺癌,乳腺癌,前列腺癌,结肠直肠癌,白血病和淋巴瘤等特定癌症与心血管疾病密切相关,脏癌和胰腺癌也由于共同风险和心脏毒性癌症疗法而显示出显著的关联.
研究的目的:
- 检查心血管疾病和癌症之间的共同风险因素.
- 审查生活方式修改和药理干预措施在预防和管理这两种疾病中的作用.
- 强调对心血管和瘤健康的交叉路口的流行病学和机械学见解.
主要方法:
- 对共享风险因素,生活方式干预和药理策略的现有文献的审查.
- 对心血管药物热效应的临床前和观察性研究的分析.
- 对GLP-1RA,SGLT2is,inclisiran和sacubitril/valsartan等新型治疗剂在调节癌症相关途径和心血管健康方面的新兴证据的审查.
主要成果:
- 改变生活方式 (体力活动,饮食,戒烟/戒酒) 有效地减少心血管疾病和癌症的发病率和死亡率.
- 心血管疾病的药物 (他类药物,阿司匹林,β抑制剂,甲胺) 显示出潜在的抗质性质.
- 像GLP-1RA和SGLT2is这样的新型药物显示出心脏保护和代谢益处,在与癌症相关的代谢中扮演着新兴的角色. 英克利西兰和萨库比特里尔/瓦尔萨坦也具有潜在的益处.
结论:
- 心血管疾病和癌症之间存在显著的相互作用,由共同的风险因素和机制驱动.
- 生活方式干预和特定的心血管疗法都具有预防癌症和改善癌症患者治疗结果的潜力.
- 进一步的研究至关重要,以阐明连接这些条件的确切机制,并充分评估心血管治疗在癌症预防和管理中的潜力.
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