老年糖尿病患者的肠道微生物群和代谢失调:是否存在性别特异性影响?
Magdalena Piłot1, Sylwia Dzięgielewska-Gęsiak1, Katarzyna Weronika Walkiewicz1
1Department of Internal Diseases Propaedeutics and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Piekarska 18, 44-902 Bytom, Poland.
Journal of clinical medicine
|May 14, 2025
概括
在患有2型糖尿病的老年患者中,性行为并没有显著改变肠道微生物群的多样性. 然而,特定的肠道细菌与代谢参数的关联在男性和女性之间有所不同,这表明性别影响微生物群-代谢相互作用.
科学领域:
- 微生物学 微生物学
- 老年学是指老年学的学科.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 老年人的2型糖尿病 (T2D) 与肠道微生物组的改变有关.
- 了解T2D肠道微生物组的性别特异性对于个性化医学至关重要.
研究的目的:
- 研究2型糖尿病的老年患者肠道细菌微生物组中的性别差异.
- 探索肠道微生物群,血糖控制和脂质障碍之间的关联,考虑性别.
主要方法:
- 用16S rRNA基因测序分析了60名老年T2D患者 (38名女性,22名男性) 的肠道微生物群.
- 使用统计分析,包括相关性和多重回归,以确定微生物种类和代谢参数之间的关系.
- 参与者接受了甲胺或甲胺和胰岛素的治疗.
主要成果:
- 两性之间没有发现肠道微生物群α或β多样性的显著差异.
- 在男性中,Tenericutes细菌系与HbA1c.c.正相关.
- 在女性中,Verrucomicrobia和Parcubacteria与HbA1c和其他指标 (G0') 有负相关性.
结论:
- 生物性别对老年T2D患者的肠道微生物群多样性没有显著影响.
- 观察到肠道微生物种群和代谢参数之间的性别特定关联.
- 这些发现强调了在T2D肠道微生物组研究中考虑年龄和性别的重要性.
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