探索抗生素耐药性模式在大肠杆菌从尿路感染分离:一个回顾性研究
Rama Alkhawaldeh1, Lobna Gharaibeh2, Amer Hayat Khan1
1Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau 11700, Penang, Malaysia.
Journal of clinical medicine
|May 14, 2025
概括
在大肠杆菌尿路感染中抗生素耐药性是一个越来越令人担忧的问题. 这项在约旦的研究发现了显著的耐药性,强调需要更新的敏感性概况和量身定制的抗生素治疗,以获得更好的患者结果.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床药房 临床药房
背景情况:
- 尿路感染 (UTI) 很常见,大肠杆菌 (E. coli) 是主要的致病原体.
- 抗菌素耐药性增加需要更新抗生素敏感性概况以进行有效的治疗.
- 经验性抗生素治疗尿路感染需要准确的局部耐药性数据来确保疗效.
研究的目的:
- 更新约旦成年患者中引起尿路感染的大肠杆菌对抗生素敏感性概况.
- 评估大肠杆菌对常用实证抗生素的耐药性模式.
- 提供数据,以指导在尿路感染管理中选择适当的抗生素.
主要方法:
- 从2019年1月到2021年7月,对大肠杆菌尿路感染病例的回顾性分析.
- 数据收集包括患者人口统计,处方经验性抗生素和大肠杆菌培养结果.
- 使用基于敏感性测试的临床断点来确定抗生素耐药性.
主要成果:
- 在230例大肠杆菌尿路感染病例中,87.4%接受了经验性抗生素.
- 抗生素敏感性测试显示,27%的大肠杆菌分离物对至少一种药物有抗性.
- 与男性 (30.8%) 相比,女性患者表现出更高的耐药大肠杆菌 (51.5%) 的患病率.
结论:
- 大肠杆菌对实证抗生素具有显著的耐药性,这强调了需要持续监测的必要性.
- 根据患者特异性因素和局部耐药性数据量身定制抗生素治疗至关重要.
- 改善抗生素管理可以提高临床结果,并打击抗菌素耐药性.
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