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相关概念视频

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

222
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
222

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相关实验视频

Updated: May 6, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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工程组织模型解码宿主微生物群相互作用.

Miryam Adelfio1, Grace E Callen1, Xuesong He2

  • 1Department of Biomedical Engineering, University of Massachusetts-Lowell, Lowell, MA, 01854, USA.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|May 14, 2025
PubMed
概括
此摘要是机器生成的。

与宿主相关的微生物群保持健康,但失生症可能导致疾病. 本综述探讨了用于研究宿主微生物群相互作用和开发新疗法的体外模型.

关键词:
这种疾病叫做dysbiosis.女性生殖道的女性生殖道.主体与微生物群的相互作用.我们的肠道是肠道.通过口腔的口腔口腔.皮肤 皮肤 皮肤组织模型,组织模型.

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科学领域:

  • 微生物学 微生物学
  • 人体生理学 人体生理学
  • 疾病的病原发生 疾病的病原发生

背景情况:

  • 人体与其微生物群之间存在共生关系,这对局部组织功能和整体生物体健康至关重要.
  • 微生物群组成的变化,称为失生症,破坏宿主相互作用,并可能导致疾病,甚至影响远处的器官.
  • 了解失生症的机制是恢复组织平衡和预防疾病的关键.

研究的目的:

  • 审查当前的体外宿主微生物群研究策略.
  • 为开发生态的先进体外模型提供路线图.
  • 突出治疗开发和验证的新兴体外方法.

主要方法:

  • 对现有关于体外宿主微生物群研究的文献的调查.
  • 分析创建生理学上相关的体外模型的策略.
  • 检查支持治疗验证的新兴技术.

主要成果:

  • 在体外模型为研究利基特定宿主微生物群相互作用提供了高可靠性平台.
  • 在生理学上相关的体外模型对于调查微生物群在健康和疾病中的作用至关重要.
  • 新兴的体外策略与治疗开发的监管进步保持一致.

结论:

  • 先进的体外模型对于剖析复杂的宿主微生物群相互作用至关重要.
  • 开发这些模型将增强我们对失生症及其病理学的理解.
  • 在体外研究对于加速新疗法的验证和进入市场至关重要.