中国多中心对心律失常心肌病风险评估的队列研究 (ChinaCORE ACM) 注册表
Yuxiao Hu1, Zhongli Chen2, Anteng Shi3
1State Key Laboratory of Cardiovascular Disease, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
这项研究建立了ChinaCORE ACM注册表,这是一个中国心律失常心肌病 (ACM) 患者的国家队列. 该注册旨在改善对这种独特人群中ACM的理解和风险预测.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 在中国,心律失常性心肌病 (ACM) 呈现出不同的遗传和临床特征.
- 针对中国ACM患者量身定制的预后模型存在重大差距.
研究的目的:
- 创建一个大型的国家ACM患者队列,提供高质量的标准化数据.
- 为中国ACM患者提供未来风险预测模型.
主要方法:
- 确定/边缘ACM和基因型阳性亲属的患者的招募.
- 综合的基线数据收集:病史,心电图,成像,遗传学,实验室.
- 对心力衰竭和心室节律失常的纵向结果跟踪.
主要成果:
- 中国CORE ACM注册表包括622名参与者 (552名受试者).
- 对577名患者的初步分析显示,495人被诊断为心律失常的右心室心肌病变.
- 恶性心室节律失常 (40.1%) 和末期心力衰竭 (21.9%) 的高患病率.
结论:
- 中国CORE ACM注册表是一个全国性的,纵向的,观察性队列研究.
- 这一举措增强了对中国人群中ACM疾病谱的理解.
- 该注册表将有助于提高ACM的预后准确性.
更多相关视频
03:45Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
08:03Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
Published on: October 20, 2022
相关概念视频
Pulse Assessment Sites
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Imaging Studies for Cardiovascular System IV: CMRI
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Acute Coronary Syndrome III: Diagnostic Studies
