上和诺上注入在预防低血压后宫下关节阻塞在剖腹产的比较:一个随机的,双盲研究
Omer M Mujahid1, Mamta Sinha2, Mayank Kumar2
1Cardiac Anesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, New Delhi , IND.
上腺素和上腺素输注在预防剖腹产期间的低血压方面同样有效. 然而,上腺素更安全,因为它不会像上腺素那样引起心肌梗塞.
科学领域:
- 产科和妇科 产科和妇科
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在脊髓麻醉下进行剖腹产时,预防性血管压缩剂输液是预防低血压的标准.
- 上腺素正在成为上腺素的替代品,因为它降低了反射性心的风险.
研究的目的:
- 为了比较上腺素与上腺素在预防剖腹产期间脊柱后低血压的疗效.
- 评估上腺素 (norepinephrine) 和上腺素 (phenylephrine) 的安全性概况,重点关注孕产妇的心,恶心,吐和新生儿结局.
主要方法:
- 一项前性,随机,双盲研究,涉及102名分娩妇女 (ASA身体状况2) 接受剖腹产.
- 参与者接受了上腺素或上腺素输注,输注速率由手动调整.
- 主要结局:预防脊柱后低血压;次要结局:孕产妇的胸肌梗塞,恶心,吐和新生儿带血液气体参数.
主要成果:
- 低血压的发生率在诺阿基尼和上腺素组之间是相似的 (27.08%对比21.28%).
- 与上腺素组 (0%) 相比,上腺素组经历了显著更高的胸肌梗塞率 (19.15%) .
- 恶心,吐,医生干预和新生儿带血的ABG参数在两组之间是可比的.
结论:
- 上腺素和上腺素输液在剖腹产期间预防低血压方面表现出类似的有效性.
- 上腺素提供了显著的安全优势,通过避免与上腺素预防相关的胸肌梗塞.
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