患者和提供者对长效结核病预防治疗的偏好
M Vermeulen1, K K Scarsi2, R Furl3
1Department of Medicine and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.
IJTLD open
|May 14, 2025
概括
长效注射性结核病预防疗法 (TPT) 是患者最喜欢的,医疗保健提供者认为是可行的. 解决有关成本,有效性和安全性的担忧可以改善其在结核病消除方面的采用.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 制药科学 制药科学
背景情况:
- 结核病预防疗法 (TPT) 对于结核病的消除至关重要,但由于使用不足而面临挑战.
- 长效 (LA) 配方的TPT提供了潜在的改善患者的坚持和治疗结果.
研究的目的:
- 评估患者对各种长效 (LA) 制剂的偏好和关注,以预防结核病治疗 (TPT).
- 评估在低收入和中等收入国家 (LMICs) 的医疗保健提供者 (HCPs) 中对LA-TPT的感知实施可行性.
主要方法:
- 在印度和南非的409名患者中进行了一项横截面面对面调查,将口服药丸与LA注射,植入物和微阵列贴片 (MAP) 进行比较.
- 与此同时,在LMIC中的94名HCP进行了在线调查,评估了实施LA-TPT的可行性.
- 用描述性统计数据分析了数据.
主要成果:
- 注射式LA-TPT是患者中最喜欢的配方 (75%的愿意尝试),其次是药丸,植入物和MAPs.
- 医疗保健提供者更喜欢注射式LA-TPT (43%),其次是口服药片 (26%).
- 患者的担忧主要集中在潜在的无效和长期的副作用上,而医疗保健专家则将成本视为一个重要的采用障碍.
结论:
- 注射式LA-TPT在患者中表现出高接受度,在卫生保健工作者中表现出可行性.
- 解决与成本,有效性和安全相关的问题对于成功实施和更广泛地采用LA-TPT至关重要.
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