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Updated: Jun 15, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

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为TRIM25发现和优化一种共价配体,并将其应用于向蛋白质无化

Katherine A McPhie1, Diego Esposito1, Jonathan Pettinger2

  • 1Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute 1 Midland Road London NW1 1AT UK katrin.rittinger@crick.ac.uk.

Chemical science
|May 14, 2025
PubMed
概括

研究人员确定了TRIM25的新型共价配体,增强了其活性,并使向蛋白质无化成为可能. 这一发现推进了TRIM E3酶的诱导近距离领域.

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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

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