卵子细胞与光滑的内等离子网聚合物可能不会影响分裂试管婴儿-ICSI授精的生殖结果:一项回顾性研究
Yejuan Li1, Jiajia Hu1, Hui Lu1
1Reproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Frontiers in endocrinology
|May 14, 2025
概括
卵细胞中的光滑内质网膜聚合物 (SERa) 与更高的雌激素水平和更多的取回卵相关. 然而,SERA的存在不会对IVF-ICSI结果或新生儿健康产生负面影响.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精 (IVF)
背景情况:
- 在卵细胞中观察到光滑的内质网膜聚合物 (SERa).
- 在卵细胞中SERA的临床意义尚不清楚.
- 了解SERA的影响对于优化IVF-ICSI结果至关重要.
研究的目的:
- 调查SERA在卵细胞对胚胎和临床结果的影响.
- 为了评估SERA对新生儿结局在分割IVF-ICSI周期的影响.
- 确定在卵巢刺激期间SERA和激素水平之间的关系.
主要方法:
- 从2020年1月到2023年12月的临床数据的回顾性分析.
- 患者被分为SERa阳性 (SERa+) 和SERa阴性 (SERa-) 组.
- 组间患者特征,胚胎学,临床和新生儿结局的比较.
主要成果:
- 在SERA+周期中,hCG一天的E2水平显著提高,卵细胞检索量增加 (P<0.01).
- 在SERA+周期 (P<0.01) 中观察到更高的D3高质量胚胎率,特别是ICSI.
- 在SERA+和SERA-组之间没有发现怀孕,植入,活产或新生儿结局的显著差异.
结论:
- 卵细胞中SERA的发生可能与hCG当天E2水平升高有关.
- 存在SERA似乎不会对IVF-ICSI胚胎学,临床或新生儿结局产生不利影响.
- SERa的可见性可以作为卵巢反应的潜在指标.
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