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Updated: Jun 15, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
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Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

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推进TET抑制剂开发:从结构洞察到生物评估

Suzanne Willems1, Lejla Maksumic2, Janina Niggenaber1

  • 1Department of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD) am Zentrum für integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.

ACS medicinal chemistry letters
|May 14, 2025
PubMed
概括

十一转位 (TET) 酶调节DNA甲基化,并在表观遗传过程中至关重要. 这项研究开发了新的TET抑制剂和化学工具,推进了针对表观遗传相关疾病的治疗策略.

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

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相关概念视频

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...