细胞巨乳病毒分离到一个结肠多在一个患有性结肠炎的患者在Ozanimod治疗:一个病例报告
Zehra Naseem1, Ahmed Nadeem1, Aidan J David2
1Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Case reports in gastroenterology
|May 14, 2025
概括
在一个性结肠炎患者中发现了一种罕见的结肠中多性细胞巨乳病毒 (CMV) 感染病例. 这凸显了在UC患者中需要考虑异常结肠多发现的CMV的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 细胞巨乳病毒 (CMV) 感染通常影响免疫力低下的个体,经常呈现为结肠炎.
- 胃肠道中的多重性CMV病变非常罕见.
- 接受免疫抑制治疗的性结肠炎 (UC) 患者有机会性感染的风险,如CMV.
研究的目的:
- 报告在性结肠炎患者的结肠中单独发现的多性CMV感染病例.
- 强调在UC患者呈现异常内镜发现时考虑CMV的重要性.
- 讨论这种罕见表现的诊断和管理方面的考虑.
主要方法:
- 一名49岁的男性患者患有UC缓解在ozanimod接受了监视结肠镜检查.
- 识别了多个带有白色帽子的炎症多,并进行了活检.
- 组织病理学和CMV免疫测定证实了多体内的CMV感染;血CMVPCR结果为负.
主要成果:
- 活检揭示了具有CMV免疫染阳性的炎症性息肉,表明本地化结肠CMV感染.
- 患者对3周的瓦尔甘西克洛维尔疗程反应良好.
- 随访结肠镜检查显示持续的炎症息肉,但没有证据表明有活性的CMV.
结论:
- 这种病例呈现出一种罕见的CMV感染的表现,即结肠中孤立的多重型病变.
- 这些发现表明,在免疫功能低下的UC患者中,可能存在默默的CMV重新激活或初级感染.
- 多学科合作对于优化诊断和管理UC患者异常的CMV呈现至关重要.
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