妊娠高血压疾病中的心脏结构,功能和机制:系统性审查和元分析
Jamie J Edwards1,2, Veronica Giorgione3,4, Megan Griffiths5
1Department of Cardiology, St George's Healthcare NHS Trust, London, United Kingdom (J.J.E., E.G., E.S., E.C., A.M., R.S., J.M.O.D.).
Hypertension (Dallas, Tex. : 1979)
|May 14, 2025
概括
与健康怀孕相比,妊娠高血压障碍 (HDP) 显著损害心肌力学和改变心脏结构. 先进的心声回声学可以检测这些变化,以便更好地分层和管理HDP的风险.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 医疗成像医学成像
背景情况:
- 在全球范围内,妊娠高血压疾病 (HDP) 是孕产妇发病率和死亡率的主要原因.
- 早期发现和管理HDP对于改善母亲的结果至关重要.
研究的目的:
- 进行最大的元分析,比较HDP与健康怀孕中的心声学特征.
- 为了确定HDP中风险分层的关键心声学标记.
主要方法:
- 在PubMed和EMBASE的系统文献搜索到2024年3月.
- 包括53项研究,共7168名参与者 (3381名HDP,3787名对照).
- 传统和先进的心声回声学参数的元分析.
主要成果:
- 在HDP中心肌力学受损,由减少的全球纵向应变和左心房储应变证明.
- HDP中的显著心脏结构差异,包括左心室质量指数增加和左心房大小增加.
- 左心室填充压力升高,以较高的早期合管流入速度与早期合管环状速度的比率表示.
结论:
- 在HDP和健康怀孕之间存在临床上显著的心声学差异.
- 先进的心声回声学,特别是心肌力学,有助于检测HDP的亚临床功能障碍.
- 心声学可以增强风险分层,并指导HDP妇女的早期干预.
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