确定年轻人脉冲波速度的参考值
Vimarsha Kodithuwakku1, Monique Breslin1, Jeanne Hersant1,2
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia (V.K., M.B., J.H., S.G., R.E.C.).
Hypertension (Dallas, Tex. : 1979)
|May 14, 2025
概括
对大动脉脉冲波速度 (PWV) 的参考值在健康的年轻人中确定. 这有助于识别潜在的血管衰老和未来心血管疾病风险的年轻人.
科学领域:
- 心血管健康 心血管健康
- 血管衰老研究研究
- 儿童心脏病学 儿童心脏病学
背景情况:
- 大动脉脉冲波速 (PWV) 是成年人血管衰老和心血管风险的关键指标.
- 确定青少年PWV的参考值对于早期心血管疾病风险评估至关重要.
- 青年血管协会数据库促进了对年轻人群血管衰老的研究.
研究的目的:
- 在健康的年轻人中开发大动脉脉冲波速度 (PWV) 的参考值.
- 通过血管衰老评估,能够识别心血管疾病风险增加的年轻人.
- 为了有助于理解血管衰老趋势在年轻人的多样化,国际队列.
主要方法:
- 一项回顾性多中心研究协调了1至40岁的19,930名参与者的数据.
- 一般化添加模型被用于导出大动脉PWV的百分位曲线.
- 数据包括来自六种不同的评估设备的人口统计,人体测量,生化标志物和血管衰老测量.
主要成果:
- 大动脉PWV的参考值是为健康的年轻人构建的 (平均年龄为17岁,51%是女性,71%是欧洲人).
- 特定于设备的百分位曲线显示,大动脉PWV的趋势随着年龄的增长在两性中都有所增加.
- 参与者根据血压,BMI,葡萄糖和胆固醇水平被归类为健康.
结论:
- 这项研究为健康年轻人提供了主动脉PWV的基本参考值,按年龄和性别分层.
- 这些百分位数可以在临床上用于检测年轻人的血管衰老.
- 早期识别血管衰老可能有助于预测青少年和年轻人的未来心血管疾病风险.
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