在ALS中远程监测呼吸的声学特征的初步调查
Kathryn P Connaghan1, Marziye Eshghi2,3,4, Abigail E Haenssler1,5
1Speech and Social Interaction Lab, MGH Institute of Health Professions, Boston, Massachusetts, USA.
Muscle & nerve
|May 14, 2025
概括
基于智能手机的声学分析,特别是百分比暂停时间,显示了在家中监测肌缩侧面硬化症 (PALS) 患者的呼吸功能. 这种方法与临床测量有很好的相关性,为远程评估提供了低负担的方法.
科学领域:
- 生物医学工程 生物医学工程
- 肺部病理学 肺部病理学
- 数字健康数字健康
背景情况:
- 肌缩侧面硬化症 (ALS) 显著影响呼吸功能,需要可靠,低负荷的监测方法.
- 目前对PALS的家庭监测是有限的,因此需要可访问和客观的工具.
研究的目的:
- 评估来自智能手机录制的语音任务的声学特征的有效性,以评估PALS的呼吸功能.
- 确定声学测量是否可以作为临床上有意义的结果指标,用于ALS的呼吸系统健康.
主要方法:
- 三十六名PALS参与者接受了临床内螺旋测量 (Slow Vital Capacity - SVC).
- 参与者通过智能手机应用程序记录了段落读数,以提取声学特征 (说话速度,暂停时间).
- 相关性和ROC分析评估了声学特征与SVC/ALSFRS-RSE呼吸器分级分数之间的关系.
主要成果:
- 百分比休息时间与SVC (r=-0.62) 和ALSFRS-RSE呼吸器亚级评级 (r=-0.43) 显著相关.
- 发言速度与呼吸测量没有显著的相关性.
- 百分比休息时间在ROC分析中被证明是有用的,用于根据SVC和ALSFRS-RSE值对PALS进行呼吸干扰的分类.
结论:
- 智能手机录制的语音声学分析,特别是百分比暂停时间,是PALS中远程呼吸监测的一个有希望的非侵入性工具.
- 这种数字健康方法提供了一种可行的和临床相关的方法来评估ALS患者的呼吸功能.
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