工程长期控制的药物释放从生物降解设备3D打印与聚合的聚合
Hafiz Busari1,2, O Thompson Mefford2,3,4, M Aaron Vaughn1,3
1Poly-Med, Inc., Anderson, SC 29625, USA. aaron.vaughn@poly-med.com.
Journal of materials chemistry. B
|May 14, 2025
概括
通过3D打印生物降解树脂和聚合,可以创建针对患者的药物输送设备. 修改打印几何学可以控制设备的降解,从而使长期治疗应用中持续释放药物.
科学领域:
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
- 3D打印技术的发展
背景情况:
- 瓦特聚合 (VP) 3D打印为患者特定的药物输送设备提供复杂几何形状的高分辨率制造.
- 目前的限制包括使用缓慢降解树脂,导致扩散控制的药物释放和缺乏长期控制.
- 设备降解在3D打印设备中实现可控药物释放中的作用尚未完全理解.
研究的目的:
- 通过使用可生物降解聚树脂的VP3D打印来研究降解对药物释放动态的影响.
- 探索如何修改几何参数影响设备降解和药物释放.
- 建立对利用降解来控制长期药物释放的基本理解.
主要方法:
- 使用聚合 (VP) 3D打印,使用装载罗达胺B (RhB) 的快速降解聚树脂作为模型药物.
- 系统地改变几何参数,包括表面积与体积的比例,支柱梁大小和孔径大小.
- 量化了这些几何修改对设备降解和RhB释放配置文件的影响.
主要成果:
- 打印几何学显著影响了3D打印设备的降解率.
- 定制几何参数使RhB的长期控制释放成为可能.
- 降解控制释放的开始被确定为实现恒定的药物释放率的关键因素.
结论:
- 使用可生物降解树脂的VP3D打印为工程长期控制药物释放装置提供了一个可行的平台.
- 对降解的几何控制是实现可预测和持续药物递送的关键.
- 这项研究提供了对优化临床应用3D打印可生物降解设备的见解.
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