镇静对极度早产婴儿呼吸机诱导的隔膜功能障碍的影响
Yusuke Hoshino1,2, Junichi Arai1, Koji Hirono2
1Department of Neonatology, Ibaraki Children's Hospital, Mito, Japan.
Pediatric pulmonology
|May 14, 2025
概括
镇静可能对需要机械通风的极度早产婴儿 (EPI) 的隔膜功能产生负面影响. 需要进一步的研究来证实对隔膜厚度和加厚分数的这些发现.
科学领域:
- 新生儿重症监护的新生儿重症监护
- 儿科呼吸系统医学 儿科呼吸系统医学
- 超声波诊断 超声波诊断 超声波诊断
背景情况:
- 呼吸机诱导的隔膜功能障碍是严重患病的婴儿的一个重大问题,与不良结果有关.
- 在早产婴儿中加剧腹膜功能障碍的确切机制和危险因素仍然不完全理解.
- 超声波提供了一种非侵入性的方法来评估隔膜功能.
研究的目的:
- 为了研究镇静对接受机械通风的极度早产婴儿 (EPI) 隔膜功能的影响.
- 为了比较镇静剂和非镇静剂EPI之间的隔膜超声波参数.
主要方法:
- 一项前性观察性研究涉及30名EPI,需要在出生后6小时内进行机械通风.
- 隔膜超声波测量了终端呼气 (Tde) 和终端吸气 (Tdi) 厚度,并在0日和1日计算了隔膜加厚分数 (DTF).
- 接收连续芬太尼的婴儿被归类为被镇静的婴儿;其他婴儿没有被镇静.
主要成果:
- 两组之间没有观察到Tde,Tdi或DTF的显著基线差异.
- 这两组从第0天到第1天都出现了Tde,Tdi和DTF的减少.
- 在对妊娠年龄和出生体重进行控制后,镇静与Tde,Tdi和DTF (p <0.05) 的显著较大降低有关.
结论:
- 这项试点研究表明,镇静可能会对通风式EPI的隔膜功能产生不利影响.
- 需要进行更大规模,更强大的研究来验证这些初步发现及其临床影响.
更多相关视频
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
6.5K
05:39Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
1.4K
相关概念视频
Skeletal Muscle Relaxants: Adverse Effects
314
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
314
Mechanical Ventilation I: Indication and Settings
119
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
119
Endotracheal Tube Extubation
241
Endotracheal tube extubation is a critical procedure in weaning patients from mechanical ventilation. It involves physically removing the oral or nasal endotracheal (ET) tube, marking the final step in liberating a patient from ventilatory support.
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
241
Mechanical Ventilation II: Invasive Ventilation
75
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
75
Stages of General Anesthesia
314
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
314
Mechanical Ventilation III: Noninvasive Ventilation
58
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
58
