糖双和氨基的超分子共聚化改善了神经元的存活率

相关实验视频

Updated: May 15, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

11.7K

Zijun Gao1, Ruomeng Qiu1, Dhwanit R Dave2

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|May 14, 2025
PubMed
概括

为了对抗神经退行性疾病,开发了与三糖结合的双 (TPA). 这些TPA通过形成超分子共聚物抑制了粉样β聚合并改善了神经元的存活率.

更多相关视频

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

7.2K
Rapid Generation of Amyloid from Native Proteins In vitro05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.1K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.1K