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Updated: May 15, 2025

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磁性:一个网络服务器来获取基因网络,基于发起者的基因分布

Atreyi Chakraborty1, Saksham Srimali1, Rohan Topno1

  • 1Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra 411008, India.

Nucleic acids research
|May 14, 2025
PubMed
概括

MAGNETIC 网络服务器通过分析人类基因促进体中的基因丰度来识别基因调节网络. 这种工具有助于发现基因连接和理解基因调节,有助于识别潜在的蛋白质结合部位.

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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