创伤后应激症和表观遗传衰老:一个纵向的元分析
Xiang Zhao1, Seyma Katrinli2, Beth M McCormick3,4
1Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Psychological medicine
|May 14, 2025
概括
患上创伤后应激障碍 (PTSD) 或症状恶化加速表观遗传衰老. 这项纵向研究表明,PTSD可能加快生物衰老,强调需要治疗研究.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 精神病学是一个精神病学.
- 纵向研究 纵向研究
背景情况:
- 创伤后应激障碍 (PTSD) 与先进的表观遗传年龄有关,但纵向关联仍然不清楚.
- 这项研究研究了PTSD发展/严重性变化和随着时间的推移表观遗传衰老之间的关系.
研究的目的:
- 为了确定新发病的PTSD和PTSD症状严重程度的变化是否与表观遗传年龄加速/减缓有关.
- 分析来自军事和民用队伍的纵向数据.
主要方法:
- 来自精神病基因组学联盟PTSD表观遗传学工作组的7个队伍 (N=1,367) 的元分析.
- 使用Horvath和GrimAge指标检查表观遗传年龄加速/减速的变化.
- 评估了基线表观遗传年龄与PTSD随时间变化之间的相互作用.
主要成果:
- 新发病的PTSD与随着时间的推移增加的Horvath表观遗传年龄加速显著相关 (meta β=0.16, p=0.02).
- 增加的PTSD症状严重程度也与更大的Horvath年龄加速相关 (meta β=0.24, p=0.05).
- 对于GrimAge指标,没有发现任何显著的关联.
结论:
- 患有PTSD或经历症状恶化的个体表现出加速表观遗传衰老.
- 这些发现表明,PTSD可能会纵向加速生物衰老.
- 需要进行进一步的研究,以探索PTSD治疗是否可以减轻甲基组上加速衰老的影响.
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