人类乳头瘤病毒在儿童早期的持续性,复发和发生率
Eméra Alice Bénard1,2, Ana Maria Carceller2,3, Marie-Hélène Mayrand4,5
1Department of Social and Preventive Medicine, Université de Montréal, Montreal, Québec, Canada.
The Journal of infectious diseases
|May 14, 2025
概括
人类乳头瘤病毒 (HPV) 的垂直传播发生在7.3%的新生儿中. 虽然新型HPV感染可能发生在婴儿身上,但儿童持续或复发性HPV的风险非常低.
科学领域:
- 病毒学 病毒学
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 人类乳头瘤病毒 (HPV) 从母亲传播给孩子的情况尚不清楚.
- 儿童HPV感染的动态需要进一步调查.
研究的目的:
- 为了确定HPV从母亲向新生儿垂直传播的风险.
- 评估HPV感染在2岁以下儿童中的发生率,持续性和复发情况.
主要方法:
- 前性队列研究 (HERITAGE) 涉及孕妇及其从出生到两岁的孩子.
- 定期对母体阴道样本和婴儿样本 (结膜,口腔,喉,生殖器) 进行HPVDNA测试.
- 使用统计方法和卡普兰-梅尔分析估计HPV垂直传播概率,发病率,持久性和清除时间.
主要成果:
- 据估计,从HPV阳性母亲出生的婴儿中有7.3%的婴儿垂直获得HPV,基因型一致性为85.2%.
- 在随访期间,9.6%的儿童经历了发生的HPV基因型.
- 大多数儿童的HPV感染自发清除,平均清除时间为3.9个月;只观察到2种复发性和1种持久性感染.
结论:
- 垂直传播的HPV和新的HPV感染可以发生在婴儿中.
- 儿童在生命的头两年内持续或复发的HPV感染的风险显著较低.
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