在硫酸德克斯诱导的性结肠炎中,取物-脂复合物的Aegle marmelos对大鼠的影响
Pooja Ganpat Swami1, Dilesh Jagdish Singhavi1, Rajendra Onkarappa Ganjiwale1
1Institute of Pharmaceutical Education and Research, Wardha, India.
Turkish journal of pharmaceutical sciences
|May 14, 2025
概括
一种新型的脂复合物 - - Aegle marmelos水果提取物 (AMEP) - - 在性结肠炎的老鼠模型中显著降低了氧化应激和炎症标志物,显示出作为有效治疗的前景.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
- 自然产品 自然产品
背景情况:
- 阿尤尔韦达医学利用瓜水果治疗胃肠道问题,但其多的生物可用性较差.
- 性结肠炎 (UC) 是一种慢性炎症疾病,需要改进治疗策略.
研究的目的:
- 开发和优化瓜提取物-脂 (AMEP) 复合物,以提高口服生物可用性.
- 为了比较AMEP与普通提取物 (AME) 和梅萨拉胺在硫酸 (DSS) 诱导的性结肠炎大鼠模型中的 in vivo 疗效.
主要方法:
- 使用溶剂蒸发来制备AMEP,并通过Box-Behnken设计进行优化.
- 描述包括SEM,FTIR,DSC,泽塔潜力和粒子大小分析.
- 在体内研究涉及DSS诱导的老鼠模型来评估氧化应激标志物 (NO,MDA,SOD) 和炎症类细胞因子 (TNF-α,IL-6).
主要成果:
- 鉴定证实了AMEP的形成,粒子大小为673.6±4.30 nm,泽塔电位为-42.6 mV±0.51.
- 艾美普治疗显著降低了NO,MDA,TNF-α和IL-6水平 (p<0.0001到p<0.01).
- 与普通AME组相比,AMEP显著增加了SOD活性 (p<0.05).
结论:
- 开发的AMEP显示了性结肠炎的增强治疗潜力.
- 艾美普有效地减轻氧化应激和炎症,这表明它是一个有前途的新疗法.
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