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轻度至中度肝功能障碍对瓦莱梅托斯塔特药理动学的影响:一项开放式标签I期研究

Masaya Tachibana1, Thuy Vu Craveiro2, Thomas C Marbury3

  • 1Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd, Tokyo, Japan.

Clinical pharmacology in drug development
|May 14, 2025
PubMed
概括

作为EZH2/EZH1抑制剂的瓦莱梅托斯酸盐在患有轻度至中度肝功能障碍的患者中没有显著的安全问题. 对于这些患者,不建议进行剂量调整.

关键词:
在 EZH2 中使用.第一个阶段I阶段临床试验临床试验临床试验临床试验临床试验肝功能受损 肝功能受损人类 人类 人类 人类 人类 人类 人类药物动力学 药物动力学值得一提的是气象状况.α1 - 酸性糖蛋白是一种α1 - 酸性糖蛋白.

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