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具有代谢功能障碍相关性肝病 (MASLD) 个体的人类测量和死亡风险:基于人口的队列研究

Yee Hui Yeo¹, Yixuan Zhu², Jingli Gao³

¹Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, California, Los Angeles, USA.

Alimentary pharmacology & therapeutics

|May 14, 2025

概括

腰围 (WC) 和相关指数比体重指数 (BMI) 更好地预测代谢功能障碍相关的脂肪性肝病 (MASLD) 的死亡率. 建议进行常规的WC测量,以改善MASLD预后.

科学领域:

代谢功能障碍相关的脂肪性肝病 (MASLD) 研究
在临床预后中进行人体测量测量.
公共卫生和流行病学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
体重指数 (BMI) 是评估MASLD风险的常见但潜在有限的衡量标准.
腹部脂肪分布,更好地通过腰围 (WC) 表示,在MASLD中至关重要.

研究的目的:

在MASLD中比较BMI,WC和WC相关指数 (WHR,BSI,WWI) 的预后值.
为了确定基于WC的测量是否比BMI更好地预测死亡风险.
调查人体测量测量和MASLD严重程度之间的关联.

主要方法:

对四个大规模队列的分析:NHANES (2017-2020,III),Kailuan和英国生物银行.
使用多变量Cox比例危险回归和限制性立方线来评估死亡风险.
评估了人体测量和肝硬化/纤维化之间的皮尔森相关系数.

主要成果:

与WC和WC相关的指数 (WHR,BSI,WWI) 在MASLD中显示出显著的死亡风险梯度,与BMI不同.
WC与肝硬化和纤维化的相关性比BMI更强.
随着WC相关指数的四分位数较高,MASLD和纤维化患病率增加;与WC相关指数较高的低BMI表明死亡率最高.

结论:

在MASLD中,WC和WC相关的指数在预后方面优于BMI.
与BMI相关的"肥胖悖论"可能源于使用不充分的指标.
建议对MASLD患者进行常规的WC测量,以改善风险评估.

关键词:

身体质量指数 (BMI) 是指身体质量指数.身体形状指数身体形状指数肥胖的悖论肥胖的悖论内脏脂肪的脂肪性是什么腰围腰围腰围腰围体重调整后的腰部指数.

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