降低血压和癌症风险:个体参与者级数据元分析和门德尔随机化研究
Milad Nazarzadeh1, Emma Copland2, Karl Smith Byrne3
1Deep Medicine, Oxford Martin School, University of Oxford, Oxford, United Kingdom; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.
JACC. CardioOncology
|May 14, 2025
概括
长期的降血压药物并没有显著增加或减少癌症风险. 这项对随机试验的大型元分析发现,对发生的癌症或癌症死亡没有实质性的影响.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 有关长期使用抗高血压药物和癌症风险存在担忧.
- 随机对照试验 (RCT) 对这一主题的证据有限,大多数数据来自观察性研究.
研究的目的:
- 评估长期降低血压对新发癌症风险的影响.
- 评估对特定原因癌症死亡率和特定癌症发病地的影响.
主要方法:
- 来自42个RCT的个人参与者数据被汇总在一起进行元分析.
- 使用考克斯比例危险回归,对特定癌症的网站进行门德尔随机化.
- 主要结局是发生的癌症;次要结局包括癌症死亡和特定癌症类型.
主要成果:
- 对314,016名参与者的分析显示,血压降低与整体癌症风险或死亡之间没有关联.
- 在随访期间或在基线子组中没有观察到显著的影响.
- 发现了与肺癌的潜在联系,但并没有得到孟德尔随机化的支持.
结论:
- 药理降低血压似乎没有显著影响患癌症的风险.
- 没有证据表明它会影响癌症死亡率或特定癌症类型.
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