初步[18F]FDG PET/CT研究,用于评估肺移植患者的存活率,这些患者患有间歇性肺病
Lin Chen1,2,3, Jing Wang1,2,3, Chentao Jin1,2,3
1Department of Nuclear Medicine and Medical PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
概括
[18F]FDG PET/CT在预测患有间歇性肺病的肺移植患者的存活率方面表现有希望. 这种成像技术可能有助于评估这些患者的长期结果.
科学领域:
- 核医学是一种核医学.
- 放射学 放射学是一门学科.
- 胸部外科手术 胸部外科手术
背景情况:
- 间歇性肺部疾病 (ILD) 是一组渐进的纤维化肺部疾病.
- 肺移植 (LTx) 是末期ILD的治疗选择.
- 预测LTx后的存活率对于患者管理至关重要.
研究的目的:
- 评估[F]氧糖 ([F]FDG) 定子发射断层扫描/计算机断层扫描 (PET/CT) 在预测接受LTx的ILD患者的整体存活率 (OS) 中的实用性.
- 确定在LTx后的ILD患者的临床和成像预测者.
主要方法:
- 对接受LTx.治疗的83名ILD患者的回顾性分析.
- [18F]在LTx之前进行的FDG PET/CT扫描.
- 单变量和多变量分析以确定OS的独立预测因子.
- 皮尔森的相关性分析,以评估术后体外膜氧化 (ECMO) 时间和PET/CT参数之间的关系.
主要成果:
- 手术后的ECMO时间,年龄和乳酸脱酶 (LDH) 是单边LTx.中OS的独立预测因素.
- 在双边的LTx.中,LDH和性别预测的OS.
- [18F]FDG吸收 (非移植肺的SUVmax) 是单边LTx.中OS的独立预测因子.
- SUVmin显示了在双边LTx中预测OS的趋势.
- 增加的葡萄糖代谢 (SUV平均值,SUV总值,TLG) 与更长的术后ECMO时间相关.
结论:
- [18F]FDG PET/CT是一种潜在的工具,可以预测接受LTx的ILD患者的整体存活率.
- 这种成像模式可能有助于对肺移植后ILD患者的生存评估和临床决策.
关键词:
间歇性肺病 间歇性肺病肺移植 肺移植 肺移植预测生存的预测.[18F]FDG PET/CT PET/CT PET/CT [18F]FDG PET/CT PET/CT/CT [18F]FDG PET/CT PET/CT/CT [18F]FDG PET/CT/CT更多相关视频
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