带有旋转和GREB1::CTNNB1融合的子宫内膜层瘤:扩大对最近描述的实体的知识
Antonio Travaglino1,2, Damiano Arciuolo3, Susanna Ronchi4
1Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy. antonio.travaglino.ap@gmail.com.
概括
本报告详细介绍了第五例带有旋转和CTNNB1重组的子宫内膜层瘤 (ESTW-CTNNB1),这是一个罕见的妇科瘤. 这些发现证实了独特的特征,并突出了这些瘤中的SATB2阳性.
科学领域:
- 妇科病理学的病理学
- 在瘤学瘤学.
- 分子病理学分子病理学
背景情况:
- 带有旋转和CTNNB1重组的子宫内膜层瘤 (ESTW-CTNNB1) 是一种罕见的妇科瘤.
- 此前仅报告了四例病例,这凸显了这种疾病的罕见性.
研究的目的:
- 在67岁的女性中报告第五个ESTW-CTNNB1病例.
- 描述这种罕见瘤的临床病理和分子特征.
- 为了确认先前观察到的特征,并识别新的标记物.
主要方法:
- 组织病理学检查10厘米瘤.
- 针对各种标记物的免疫组织化学分析,包括β-catenin,CD10,WT1,calretinin,SATB2,ER,PR和Ki67.
- 分子分析以确定基因融合,特别是GREB1::CTNNB1.
主要成果:
- 瘤呈现出轻微非典型的上皮细胞旋转在纤维质背景的焦点性带状区域.
- 免疫组织化学显示核β-catenin,CD10,WT1,calretinin,SATB2,ER和PR的扩散阳性,其Ki67为10%.
- 分子分析证实了GREB1::CTNNB1的融合,这是ESTW-CTNNB1.1的特征.
结论:
- 本案是第五次报告ESTW-CTNNB1.1的情况.
- 这些发现证实了ESTW-CTNNB1.1独特的临床病理和分子特征.
- 在这些罕见的子宫内膜层瘤中,SATB2阳性被强调为一个重要的特征.
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