与不同类型的糖尿病前期现象有关的维生素D缺乏:基于人口的研究
Chunhua Wu1,2,3, Mengmeng Li4, Wenjuan Yang1,2,3
1Department of Clinical Nutrition, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, People's Republic of China.
Endocrine
|May 14, 2025
概括
维生素D缺乏与糖尿病前期有关. 特定的糖尿病前期类型,特别是那些由葡萄糖水平定义的类型,显示出维生素D缺乏的可能性更高.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是越来越令人担忧的,与代谢障碍有关.
- 糖尿病前期,是2型糖尿病的前体,呈现出各种血糖异常.
- 具体的糖尿病前表型与维生素D状态之间的关系需要进一步研究.
研究的目的:
- 调查维生素D缺乏与不同类型的糖尿病前期现象之间的关联.
- 为了确定特定的糖尿病前期分类是否与维生素D缺乏更为密切相关.
主要方法:
- 分析来自国家健康和营养检查调查 (2011-2016) 的数据.
- 糖尿病前期的分类为表型:孤立缺陷 (快速葡萄糖受损[IFG],葡萄糖耐受性受损[IGT],血红蛋白A1c受损[IA1c]),双缺陷或三重缺陷.
- 多变量逻辑回归用于计算几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 与正常血糖相比,糖尿病前期与维生素D缺乏的几率增加了21.6% (或1.216).
- 糖尿病前的表型结合了葡萄糖耐受性受损和禁食葡萄糖受损 (IGT+IFG) 和所有三种缺陷 (IFG+IGT+IA1c) 显示出维生素D缺乏的几率明显更高.
- 葡萄糖定义的糖尿病前期患者的维生素D缺乏率较高,与HbA1c定义的糖尿病前期患者不同.
结论:
- 糖尿病前期与维生素D缺乏的可能性增加有关.
- 葡萄糖定义的糖尿病前表型可以作为维生素D缺乏症查的更好的指标.
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