急性和长期紫外线暴露的皮肤学影响:使用便携式灯的体内研究
Christina Karampasi1, Ioannis Sfiniadakis2, Aspasia Petri3
1Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15784, Athens, Greece.
概括
便携式UV-C消毒设备对皮肤构成风险. 短期和长期暴露于UV-C辐射都可能导致严重的皮肤损伤,包括刺激,衰老和皮肤皮质过敏,这凸显了需要遵守安全措施的必要性.
科学领域:
- 皮肤病学 皮肤病学
- 摄影生物学 摄影生物学
- 公共卫生 公共卫生
背景情况:
- 便携式UV-C消毒设备在COVID-19后得到广泛使用.
- 紫外线 (UV-C) 辐射 (254nm) 可以导致皮肤和眼睛损伤,包括红血和光炎.
- 目前关于紫外线暴露的数据主要来自固定装置,而不是近距离使用的便携式设备.
研究的目的:
- 在现实的使用条件下,评估来自便携式消毒装置的紫外线辐射对小鼠皮肤的急性和长期影响.
- 为了确定紫外线C暴露的最小红细胞剂量 (MED).
- 为了评估反复暴露于UV-C的渐进性皮肤损伤.
主要方法:
- 一个体内研究使用SKH-hr1小鼠暴露在商业灯装置的UV-C辐射 (253.7nm,5Wm-2).
- 第一个阶段:单次照射剂量 (5-60 Jm-2),以确定MED.
- 第二阶段:重复暴露 (45,60,100 Jm-2),每周5次,持续25天.
主要成果:
- 一次剂量为45 Jm-2和60 Jm-2引起皮肤刺激和过早衰老的迹象 (弹性降低,纹,干燥).
- 重复暴露导致了渐进的皮肤损伤,包括皮肤变厚和动态性皮质增生症.
- 在急性和慢性UV-C暴露时观察到显著的皮肤损伤.
结论:
- 便携式UV-C设备可能会导致严重的急性和慢性皮肤损伤.
- 这些发现强调了随便携带UV-C消毒装置的现实使用相关的风险.
- 严格遵守安全指南对于防止UV-C引起的皮肤损伤至关重要.
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